Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1H-indoles

[Image: see text] A series of 3-methyl-2-phenyl-1H-indoles was prepared and investigated for antiproliferative activity on three human tumor cell lines, HeLa, A2780, and MSTO-211H, and some structure–activity relationships were drawn up. The GI(50) values of the most potent compounds (32 and 33) wer...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Med Chem Lett
Autores principales: Zidar, Nace, Secci, Daniela, Tomašič, Tihomir, Mašič, Lucija Peterlin, Kikelj, Danijel, Passarella, Daniele, Argaez, Aida Nelly Garcia, Hyeraci, Mariafrancesca, Dalla Via, Lisa
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236043/
https://ncbi.nlm.nih.gov/pubmed/32435372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00557
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares