Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1H-indoles

[Image: see text] A series of 3-methyl-2-phenyl-1H-indoles was prepared and investigated for antiproliferative activity on three human tumor cell lines, HeLa, A2780, and MSTO-211H, and some structure–activity relationships were drawn up. The GI(50) values of the most potent compounds (32 and 33) wer...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Zidar, Nace, Secci, Daniela, Tomašič, Tihomir, Mašič, Lucija Peterlin, Kikelj, Danijel, Passarella, Daniele, Argaez, Aida Nelly Garcia, Hyeraci, Mariafrancesca, Dalla Via, Lisa
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236043/
https://ncbi.nlm.nih.gov/pubmed/32435372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00557
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