Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can be inhibited at their catalytic sites or at their...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Durcik, Martina, Skok, Žiga, Ilaš, Janez, Zidar, Nace, Zega, Anamarija, Szili, Petra Éva, Draskovits, Gábor, Révész, Tamás, Kikelj, Danijel, Nyerges, Akos, Pál, Csaba, Mašič, Lucija Peterlin, Tomašič, Tihomir
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822030/
https://ncbi.nlm.nih.gov/pubmed/33374964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13010006
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