Rational design of balanced dual-targeting antibiotics with limited resistance

Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics is feasible by using a medicinal chemistry workfl...

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Bibliografiske detaljer
Udgivet i:PLoS Biol
Main Authors: Nyerges, Akos, Tomašič, Tihomir, Durcik, Martina, Revesz, Tamas, Szili, Petra, Draskovits, Gabor, Bogar, Ferenc, Skok, Žiga, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Kikelj, Danijel, Daruka, Lejla, Kintses, Balint, Vasarhelyi, Balint, Foldesi, Imre, Kata, Diána, Welin, Martin, Kimbung, Raymond, Focht, Dorota, Mašič, Lucija Peterlin, Pal, Csaba
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561186/
https://ncbi.nlm.nih.gov/pubmed/33017402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000819
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