New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity

The ATP binding site located on the subunit B of DNA gyrase is an attractive target for the development of new antibacterial agents. In recent decades, several small-molecule inhibitor classes have been discovered but none has so far reached the market. We present here the discovery of a promising n...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Durcik, Martina, Lovison, Denise, Skok, Žiga, Durante Cruz, Cristina, Tammela, Päivi, Tomašič, Tihomir, Benedetto Tiz, Davide, Draskovits, Gábor, Nyerges, Ákos, Pál, Csaba, Ilaš, Janez, Peterlin Mašič, Lucija, Kikelj, Danijel, Zidar, Nace
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016738/
https://ncbi.nlm.nih.gov/pubmed/29778894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.05.011
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