Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

[Image: see text] We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve the antibacterial activity and retain potent enzymatic activity, we sy...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Skok, Žiga, Barančoková, Michaela, Benek, Ondřej, Cruz, Cristina Durante, Tammela, Päivi, Tomašič, Tihomir, Zidar, Nace, Mašič, Lucija Peterlin, Zega, Anamarija, Stevenson, Clare E. M., Mundy, Julia E. A., Lawson, David M., Maxwell, Anthony, Kikelj, Danijel, Ilaš, Janez
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734788/
https://ncbi.nlm.nih.gov/pubmed/33329764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00416
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