Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

[Image: see text] We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve the antibacterial activity and retain potent enzymatic activity, we sy...

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Publicat a:ACS Med Chem Lett
Autors principals: Skok, Žiga, Barančoková, Michaela, Benek, Ondřej, Cruz, Cristina Durante, Tammela, Päivi, Tomašič, Tihomir, Zidar, Nace, Mašič, Lucija Peterlin, Zega, Anamarija, Stevenson, Clare E. M., Mundy, Julia E. A., Lawson, David M., Maxwell, Anthony, Kikelj, Danijel, Ilaš, Janez
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734788/
https://ncbi.nlm.nih.gov/pubmed/33329764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00416
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