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Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

[Image: see text] We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve the antibacterial activity and retain potent enzymatic activity, we sy...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Skok, Žiga, Barančoková, Michaela, Benek, Ondřej, Cruz, Cristina Durante, Tammela, Päivi, Tomašič, Tihomir, Zidar, Nace, Mašič, Lucija Peterlin, Zega, Anamarija, Stevenson, Clare E. M., Mundy, Julia E. A., Lawson, David M., Maxwell, Anthony, Kikelj, Danijel, Ilaš, Janez
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2020
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734788/
https://ncbi.nlm.nih.gov/pubmed/33329764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00416
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