Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus

[Image: see text] MurD and MurE ligases, consecutive enzymes participating in the intracellular steps of bacterial peptidoglycan biosynthesis, are important targets for antibacterial drug discovery. We have designed, synthesized, and evaluated the first d-glutamic acid-containing dual inhibitor of M...

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Détails bibliographiques
Auteurs principaux: Tomašić, Tihomir, Šink, Roman, Zidar, Nace, Fic, Anja, Contreras-Martel, Carlos, Dessen, Andréa, Patin, Delphine, Blanot, Didier, Müller-Premru, Manica, Gobec, Stanislav, Zega, Anamarija, Kikelj, Danijel, Mašič, Lucija Peterlin
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2012
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025807/
https://ncbi.nlm.nih.gov/pubmed/24900523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300047h
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