The Binding Mode of Second-Generation Sulfonamide Inhibitors of MurD: Clues for Rational Design of Potent MurD Inhibitors

A series of optimized sulfonamide derivatives was recently reported as novel inhibitors of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD). These are based on naphthalene-N-sulfonyl-D-glutamic acid and have the D-glutamic acid replaced with rigidified mimetics. Here we have defined the bind...

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Bibliographic Details
Main Authors: Simčič, Mihael, Sosič, Izidor, Hodošček, Milan, Barreteau, Hélène, Blanot, Didier, Gobec, Stanislav, Grdadolnik, Simona Golič
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527612/
https://ncbi.nlm.nih.gov/pubmed/23285193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052817
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