Conformationally restricted monosaccharide-cored glycoside amphiphiles: the effect of detergent head group variation on membrane protein stability

Detergents are widely used to isolate membrane proteins from lipid bilayers, but many proteins solubilized in conventional detergents are structurally unstable. Thus, there is major interest in the development of novel amphiphiles to facilitate membrane protein research. In the present study, we hav...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Sadaf, Aiman, Ramos, Manuel, Mortensen, Jonas S., Du, Yang, Bae, Hyoung Eun, Munk, Chastine F., Hariharan, Parameswaran, Byrne, Bernadette, Kobilka, Brian K., Loland, Claus J., Guan, Lan, Seok Chae, Pil
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233146/
https://ncbi.nlm.nih.gov/pubmed/31305987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00166
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