Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy

A new family of tandem facial glucoside/maltosides (TFG/TFMs) for membrane protein manipulation is reported. The best detergent varied depending on the hydrophobic thickness of the target protein, but ether-based TFMs (TFM-C0E, TFM-C3E or TFM-C5E) were notable for their ability to confer enhanced me...

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Опубликовано в: :Chembiochem
Главные авторы: Das, Manabendra, Du, Yang, Mortensen, Jonas S., Hariharan, Parameswaran, Lee, Hyun Sung, Byrne, Bernadette, Loland, Claus J., Guan, Lan, Kobilka, Brian K., Chae, Pil Seok
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233144/
https://ncbi.nlm.nih.gov/pubmed/30070754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800388
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