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ATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition
Replication factor C (RFC), a heteropentamer of RFC1-5, loads PCNA onto DNA during replication and repair. Once DNA synthesis has ceased, PCNA must be unloaded. Recent findings assign the uloader role primarily to an RFC-like (RLC) complex, in which the largest RFC subunit, RFC1, has been replaced w...
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| 發表在: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7229844/ https://ncbi.nlm.nih.gov/pubmed/32297953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa255 |
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