Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration

Numerous mutations that impair retrograde membrane trafficking between endosomes and the Golgi apparatus lead to neurodegenerative diseases. For example, mutations in the endosomal retromer complex are implicated in Alzheimer’s and Parkinson’s diseases, and mutations of the Golgi-associated retrogra...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Petit, Constance S., Lee, Jane J., Boland, Sebastian, Swarup, Sharan, Christiano, Romain, Lai, Zon Weng, Mejhert, Niklas, Elliott, Shane D., McFall, David, Haque, Sara, Huang, Eric J., Bronson, Roderick T., Harper, J. Wade, Farese, Robert V., Walther, Tobias C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229683/
https://ncbi.nlm.nih.gov/pubmed/32345721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913956117
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