Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration

Numerous mutations that impair retrograde membrane trafficking between endosomes and the Golgi apparatus lead to neurodegenerative diseases. For example, mutations in the endosomal retromer complex are implicated in Alzheimer’s and Parkinson’s diseases, and mutations of the Golgi-associated retrogra...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Petit, Constance S., Lee, Jane J., Boland, Sebastian, Swarup, Sharan, Christiano, Romain, Lai, Zon Weng, Mejhert, Niklas, Elliott, Shane D., McFall, David, Haque, Sara, Huang, Eric J., Bronson, Roderick T., Harper, J. Wade, Farese, Robert V., Walther, Tobias C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2020
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229683/
https://ncbi.nlm.nih.gov/pubmed/32345721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913956117
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