Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration

Numerous mutations that impair retrograde membrane trafficking between endosomes and the Golgi apparatus lead to neurodegenerative diseases. For example, mutations in the endosomal retromer complex are implicated in Alzheimer’s and Parkinson’s diseases, and mutations of the Golgi-associated retrogra...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Petit, Constance S., Lee, Jane J., Boland, Sebastian, Swarup, Sharan, Christiano, Romain, Lai, Zon Weng, Mejhert, Niklas, Elliott, Shane D., McFall, David, Haque, Sara, Huang, Eric J., Bronson, Roderick T., Harper, J. Wade, Farese, Robert V., Walther, Tobias C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229683/
https://ncbi.nlm.nih.gov/pubmed/32345721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913956117
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados