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The structural basis for inhibition of ribosomal translocation by viomycin

Viomycin, an antibiotic that has been used to fight tuberculosis infections, is believed to block the translocation step of protein synthesis by inhibiting ribosomal subunit dissociation and trapping the ribosome in an intermediate state of intersubunit rotation. The mechanism by which viomycin stab...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zhang, Ling, Wang, Ying-Hui, Zhang, Xing, Lancaster, Laura, Zhou, Jie, Noller, Harry F.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229676/
https://ncbi.nlm.nih.gov/pubmed/32341159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002888117
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