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The structural basis for inhibition of ribosomal translocation by viomycin

Viomycin, an antibiotic that has been used to fight tuberculosis infections, is believed to block the translocation step of protein synthesis by inhibiting ribosomal subunit dissociation and trapping the ribosome in an intermediate state of intersubunit rotation. The mechanism by which viomycin stab...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Ling, Wang, Ying-Hui, Zhang, Xing, Lancaster, Laura, Zhou, Jie, Noller, Harry F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229676/
https://ncbi.nlm.nih.gov/pubmed/32341159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002888117
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