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The route to transcription initiation determines the mode of transcriptional bursting in E. coli

Transcription is fundamentally noisy, leading to significant heterogeneity across bacterial populations. Noise is often attributed to burstiness, but the underlying mechanisms and their dependence on the mode of promotor regulation remain unclear. Here, we measure E. coli single cell mRNA levels for...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Engl, Christoph, Jovanovic, Goran, Brackston, Rowan D., Kotta-Loizou, Ioly, Buck, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229158/
https://ncbi.nlm.nih.gov/pubmed/32415118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16367-6
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