R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

During kidney development, WNT/β-catenin signalling has to be tightly controlled to ensure proliferation and differentiation of nephron progenitor cells. Here, we show in mice that the signalling molecules RSPO1 and RSPO3 act in a functionally redundant manner to permit WNT/β-catenin signalling and...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Vidal, Valerie PI, Jian-Motamedi, Fariba, Rekima, Samah, Gregoire, Elodie P, Szenker-Ravi, Emmanuelle, Leushacke, Marc, Reversade, Bruno, Chaboissier, Marie-Christine, Schedl, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228766/
https://ncbi.nlm.nih.gov/pubmed/32324134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53895
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