Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex Reversals

In mammals, male sex determination is governed by SRY-dependent activation of Sox9, whereas female development involves R-spondin1 (RSPO1), an activator of the WNT/beta-catenin signaling pathway. Genetic analyses in mice have demonstrated Sry and Sox9 to be both required and sufficient to induce tes...

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Autores principales: Lavery, Rowena, Chassot, Anne-Amandine, Pauper, Eva, Gregoire, Elodie P., Klopfenstein, Muriel, de Rooij, Dirk G., Mark, Manuel, Schedl, Andreas, Ghyselinck, Norbert B., Chaboissier, Marie-Christine
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531470/
https://ncbi.nlm.nih.gov/pubmed/23300469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003170
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