Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals

In mammals, testicular differentiation is initiated by transcription factors SRY and SOX9 in XY gonads, and ovarian differentiation involves R-spondin1 (RSPO1) mediated activation of WNT/β-catenin signaling in XX gonads. Accordingly, the absence of RSPO1/Rspo1 in XX humans and mice leads to testicul...

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Vydáno v:eLife
Hlavní autoři: Richardson, Nainoa, Gillot, Isabelle, Gregoire, Elodie P, Youssef, Sameh A, de Rooij, Dirk, de Bruin, Alain, De Cian, Marie-Cécile, Chaboissier, Marie-Christine
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250573/
https://ncbi.nlm.nih.gov/pubmed/32450947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53972
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