Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary

R-spondin1 is a secreted regulator of WNT signaling, involved in both embryonic development and homeostasis of adult organs. It can have a dual role, acting either as a mitogen or as a tumor suppressor. During ovarian development, Rspo1 is a key factor required for sex determination and differentiat...

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Publicado en:Oncogene
Autores principales: De Cian, M-C, Pauper, E, Bandiera, R, Vidal, V P I, Sacco, S, Gregoire, E P, Chassot, A-A, Panzolini, C, Wilhelm, D, Pailhoux, E, Youssef, S A, de Bruin, A, Teerds, K, Schedl, A, Gillot, I, Chaboissier, M-C
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241429/
https://ncbi.nlm.nih.gov/pubmed/27270435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.191
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