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Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor

The pregnane X receptor (PXR), or nuclear receptor (NR) 1I2, is a ligand-activated NR superfamily member that is enriched in liver and intestine in mammals. Activation of PXR regulates the expression of genes encoding key proteins involved in drug metabolism, drug efflux, and drug transport. Recent...

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Podrobná bibliografie
Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Cui, Wenqi, Shen, Xunan, Agbas, Emre, Tompkins, Brandon, Cameron-Carter, Hadley, Staudinger, Jeff L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228503/
https://ncbi.nlm.nih.gov/pubmed/32205367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.264762
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