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Pregnane X Receptor Is SUMOylated to Repress the Inflammatory Response
Long-term treatment of patients with the macrolide antibiotic and prototypical activator of pregnane X receptor (PXR) rifampicin (Rif) inhibits the inflammatory response in liver. We show here that activation of the inflammatory response in hepatocytes strongly modulates SUMOylation of ligand-bound...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2967404/ https://ncbi.nlm.nih.gov/pubmed/20719936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.171744 |
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