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Pregnane X Receptor Is SUMOylated to Repress the Inflammatory Response

Long-term treatment of patients with the macrolide antibiotic and prototypical activator of pregnane X receptor (PXR) rifampicin (Rif) inhibits the inflammatory response in liver. We show here that activation of the inflammatory response in hepatocytes strongly modulates SUMOylation of ligand-bound...

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Detalhes bibliográficos
Main Authors: Hu, Gang, Xu, Chenshu, Staudinger, Jeff L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967404/
https://ncbi.nlm.nih.gov/pubmed/20719936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.171744
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