Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation

The study explores the role of neddylation in early trophoblast development and its alteration during the pathogenesis of recurrent spontaneous abortion (RSA). Immunofluorescence and western blot were conducted to evaluate the expression pattern of NEDD8 protein in the first-trimester placentas of h...

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Detalhes bibliográficos
Publicado no:Mol Hum Reprod
Main Authors: Sun, Xiaohe, Tong, Xiaomei, Hao, Yanqing, Li, Chao, Zhang, Yinli, Pan, Yibin, Dai, Yongdong, Liu, Liu, Zhang, Tai, Zhang, Songying
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227182/
https://ncbi.nlm.nih.gov/pubmed/32186736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gaaa021
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