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Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer

The role and therapeutic promise of poly-ADP ribose polymerase (PARP) inhibitors in anticancer chemotherapy are increasingly being explored, particularly in adjuvant or maintenance therapy, considering their low efficacy as monotherapy agents and their potentiating effects on concurrently administer...

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Опубликовано в: :Cells
Главные авторы: Lai, Shiue-Wei, Bamodu, Oluwaseun Adebayo, Chen, Jia-Hong, Wu, Alexander TH, Lee, Wei-Hwa, Chao, Tsu-Yi, Yeh, Chi-Tai
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226837/
https://ncbi.nlm.nih.gov/pubmed/32276472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040911
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