p53 and FBXW7: Sometimes Two Guardians Are Worse than One

Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Galindo-Moreno, María, Giráldez, Servando, Limón-Mortés, M. Cristina, Belmonte-Fernández, Alejandro, Sáez, Carmen, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Perspective
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225930/
https://ncbi.nlm.nih.gov/pubmed/32316282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040985
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