Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Vaso-occlusive crisis (VOC) is the primary cause of morbidity and hospitalization in sickle cell disease (SCD); however, only 4 therapies (hydroxyurea, l-glutamine, crizanlizumab, and voxeletor) are currently approved in SCD. These agents limit the duration, severity, and frequency of crises. Activa...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Sparkenbaugh, Erica M., Chen, Chunsheng, Brzoska, Tomasz, Nguyen, Julia, Wang, Shaobin, Vercellotti, Gregory M., Key, Nigel S., Sundd, Prithu, Belcher, John D., Pawlinski, Rafal
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Red Cells, Iron, and Erythropoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225686/
https://ncbi.nlm.nih.gov/pubmed/31977004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003543
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