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X-ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance
The V27A mutation confers adamantane resistance to the influenza A matrix 2 (M2) proton channel and is becoming more prevalent in circulating populations of influenza A virus. We have used X-ray crystallography to solve structures of a spiro-adamantyl amine inhibitor bound to M2(22–46) V27A and also...
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| 發表在: | Biochemistry |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7224692/ https://ncbi.nlm.nih.gov/pubmed/31894969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00971 |
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