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Discovery of Spiro-Piperidine Inhibitors and Their Modulation of the Dynamics of the M2 Proton Channel from Influenza A Virus

Amantadine has been used for decades as an inhibitor of the influenza A virus M2 protein (AM2) in the prophylaxis and treatment of influenza A infections, but its clinical use has been limited by its central nervous system (CNS) side effects as well as emerging drug-resistant strains of the virus. W...

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Dettagli Bibliografici
Autori principali: Wang, Jun, Cady, Sarah D., Balannik, Victoria, Pinto, Lawrence H., DeGrado, William F., Hong, Mei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807247/
https://ncbi.nlm.nih.gov/pubmed/19469531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja900063s
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