X-ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance

The V27A mutation confers adamantane resistance to the influenza A matrix 2 (M2) proton channel and is becoming more prevalent in circulating populations of influenza A virus. We have used X-ray crystallography to solve structures of a spiro-adamantyl amine inhibitor bound to M2(22–46) V27A and also...

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Bibliografiska uppgifter
I publikationen:Biochemistry
Huvudupphovsmän: Thomaston, Jessica L., Konstantinidi, Athina, Liu, Lijun, Lambrinidis, George, Tan, Jingquan, Caffrey, Martin, Wang, Jun, DeGrado, William F., Kolocouris, Antonios
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224692/
https://ncbi.nlm.nih.gov/pubmed/31894969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00971
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