Development of a Selection Method for Discovering Irreversible (Covalent) Binders from a DNA-Encoded Library

DNA-encoded libraries (DELs) have been broadly applied to identify chemical probes for target validation and lead discovery. To date, the main application of the DEL platform has been the identification of reversible ligands using multiple rounds of affinity selection. Irreversible (covalent) inhibi...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Zhu, Zhengrong, Grady, LaShadric C., Ding, Yun, Lind, Kenneth E., Davie, Christopher P., Phelps, Christopher B., Evindar, Ghotas
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221453/
https://ncbi.nlm.nih.gov/pubmed/30383465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555218808454
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