DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry

[Image: see text] DNA-encoded library (DEL) technology is a powerful platform for hit identification in academia and the pharmaceutical industry. When conducting off-DNA resynthesis hit confirmation after affinity selection, PCR/sequencing, and data analysis, one typically assumes a “one-to-one” rel...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Xia, Bing, Franklin, G. Joseph, Lu, Xiaojie, Bedard, Katie L., Grady, LaShadric C., Summerfield, Jennifer D., Shi, Eric X., King, Bryan W., Lind, Kenneth E., Chiu, Cynthia, Watts, Eleanor, Bodmer, Vera, Bai, Xiaopeng, Marcaurelle, Lisa A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274064/
https://ncbi.nlm.nih.gov/pubmed/34267887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00156
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