PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72

Loss of function mutations in the PTEN-induced kinase 1 (PINK1) kinase are causal for autosomal recessive Parkinson's disease (PD) whilst gain of function mutations in the LRRK2 kinase cause autosomal dominant PD. PINK1 indirectly regulates the phosphorylation of a subset of Rab GTPases at a co...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Vieweg, Sophie, Mulholland, Katie, Bräuning, Bastian, Kachariya, Nitin, Lai, Yu-Chiang, Toth, Rachel, Singh, Pawan Kishor, Volpi, Ilaria, Sattler, Michael, Groll, Michael, Itzen, Aymelt, Muqit, Miratul M. K.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Molecular Bases of Health & Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219890/
https://ncbi.nlm.nih.gov/pubmed/32227113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190664
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