Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Mutations in the PTEN‐induced kinase 1 (PINK1) are causative of autosomal recessive Parkinson's disease (PD). We have previously reported that PINK1 is activated by mitochondrial depolarisation and phosphorylates serine 65 (Ser(65)) of the ubiquitin ligase Parkin and ubiquitin to stimulate Park...

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Vydáno v:EMBO J
Hlavní autoři: Lai, Yu‐Chiang, Kondapalli, Chandana, Lehneck, Ronny, Procter, James B, Dill, Brian D, Woodroof, Helen I, Gourlay, Robert, Peggie, Mark, Macartney, Thomas J, Corti, Olga, Corvol, Jean‐Christophe, Campbell, David G, Itzen, Aymelt, Trost, Matthias, Muqit, Miratul MK
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654935/
https://ncbi.nlm.nih.gov/pubmed/26471730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591593
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