טוען...
Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain via as yet poorly understood mechanisms. hPINK...
שמור ב:
| הוצא לאור ב: | eLife |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
eLife Sciences Publications, Ltd
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5679756/ https://ncbi.nlm.nih.gov/pubmed/28980524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29985 |
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