Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain via as yet poorly understood mechanisms. hPINK...

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Udgivet i:eLife
Main Authors: Kumar, Atul, Tamjar, Jevgenia, Waddell, Andrew D, Woodroof, Helen I, Raimi, Olawale G, Shaw, Andrew M, Peggie, Mark, Muqit, Miratul MK, van Aalten, Daan MF
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679756/
https://ncbi.nlm.nih.gov/pubmed/28980524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29985
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