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Ligand-Enabled β-Methylene C(sp(3))−H Arylation of Masked Aliphatic Alcohols

Despite recent advances, reactivity and site-selectivity remain significant obstacles for the practical application of C(sp(3))−H bond functionalization methods to synthetic chemistry. Here, we describe a system that combines a salicylic-aldehyde-derived L,X-type directing group with an electron-def...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Xia, Guoqin, Zhuang, Zhe, Liu, Luo-Yan, Schreiber, Stuart L., Melillo, Bruno, Yu, Jin-Quan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219561/
https://ncbi.nlm.nih.gov/pubmed/32050036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202000632
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