Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

Recombinant adeno-associated viruses (rAAVs) are efficient, non-invasive gene delivery vectors via intravenous delivery, however, natural serotypes display a finite set of tropisms. To expand their utility, we evolved AAV capsids to efficiently transduce specific cell types in adult mouse brains. Bu...

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Bibliografiset tiedot
Julkaisussa:Nat Methods
Päätekijät: Kumar, Sripriya Ravindra, Miles, Timothy F., Chen, Xinhong, Brown, David, Dobreva, Tatyana, Huang, Qin, Ding, Xiaozhe, Luo, Yicheng, Einarsson, Pétur H., Greenbaum, Alon, Jang, Min J., Deverman, Benjamin E., Gradinaru, Viviana
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219404/
https://ncbi.nlm.nih.gov/pubmed/32313222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-0799-7
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