Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer. Nevertheless, AAVs that provide efficient transduction across specific organs or cell populations are needed. Here, we describe AAV-PHP.eB and AAV-PHP.S, capsids that efficiently transduce the central and peripheral nervous...

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Vydáno v:Nat Neurosci
Hlavní autoři: Chan, Ken Y, Jang, Min J, Yoo, Bryan B, Greenbaum, Alon, Ravi, Namita, Wu, Wei-Li, Sánchez-Guardado, Luis, Lois, Carlos, Mazmanian, Sarkis K, Deverman, Benjamin E, Gradinaru, Viviana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529245/
https://ncbi.nlm.nih.gov/pubmed/28671695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4593
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