Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

Recombinant adeno-associated viruses (rAAVs) are efficient, non-invasive gene delivery vectors via intravenous delivery, however, natural serotypes display a finite set of tropisms. To expand their utility, we evolved AAV capsids to efficiently transduce specific cell types in adult mouse brains. Bu...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Kumar, Sripriya Ravindra, Miles, Timothy F., Chen, Xinhong, Brown, David, Dobreva, Tatyana, Huang, Qin, Ding, Xiaozhe, Luo, Yicheng, Einarsson, Pétur H., Greenbaum, Alon, Jang, Min J., Deverman, Benjamin E., Gradinaru, Viviana
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219404/
https://ncbi.nlm.nih.gov/pubmed/32313222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-0799-7
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