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Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
Recombinant adeno-associated viruses (rAAVs) are commonly used vehicles for in vivo gene transfer(1-6). However, the tropism repertoire of naturally occurring AAVs is limited, prompting a search for novel AAV capsids with desired characteristics(7-13). Here we describe a capsid selection method, cal...
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| Publicat a: | Nat Biotechnol |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5088052/ https://ncbi.nlm.nih.gov/pubmed/26829320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3440 |
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