Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

Recombinant adeno-associated viruses (rAAVs) are commonly used vehicles for in vivo gene transfer(1-6). However, the tropism repertoire of naturally occurring AAVs is limited, prompting a search for novel AAV capsids with desired characteristics(7-13). Here we describe a capsid selection method, cal...

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Udgivet i:Nat Biotechnol
Main Authors: Deverman, Benjamin E., Pravdo, Piers L., Simpson, Bryan P., Kumar, Sripriya Ravindra, Chan, Ken Y., Banerjee, Abhik, Wu, Wei-Li, Yang, Bin, Huber, Nina, Pasca, Sergiu P., Gradinaru, Viviana
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088052/
https://ncbi.nlm.nih.gov/pubmed/26829320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3440
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