Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery

The engineering of the AAV-PHP capsids was an important development for CNS research and the modulation of gene expression in the brain. They cross the blood brain barrier and transduce brain cells after intravenous systemic delivery, a property dependent on the genotype of Ly6a, the AAV-PHP capsid...

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Bibliographische Detailangaben
Veröffentlicht in:Brain Commun
Hauptverfasser: Smith, Edward J, Farshim, Pamela P, Flomen, Rachel, Jones, Samuel T, McAteer, Sean J, Deverman, Benjamin E, Gradinaru, Viviana, Bates, Gillian P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8200048/
https://ncbi.nlm.nih.gov/pubmed/34131644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcab105
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