Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia

Activating mutations in cytosolic 5′-nucleotidase II (NT5C2) are considered to drive relapse formation in acute lymphoblastic leukemia (ALL) by conferring purine analog resistance. To examine the clinical effects of NT5C2 mutations in relapsed ALL, we analyzed NT5C2 in 455 relapsed B-cell precursor...

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Veröffentlicht in:Blood
Hauptverfasser: Barz, Malwine J., Hof, Jana, Groeneveld-Krentz, Stefanie, Loh, Jui Wan, Szymansky, Annabell, Astrahantseff, Kathy, von Stackelberg, Arend, Khiabanian, Hossein, Ferrando, Adolfo A., Eckert, Cornelia, Kirschner-Schwabe, Renate
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218751/
https://ncbi.nlm.nih.gov/pubmed/31971569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002499
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