Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia

Activating mutations in cytosolic 5′-nucleotidase II (NT5C2) are considered to drive relapse formation in acute lymphoblastic leukemia (ALL) by conferring purine analog resistance. To examine the clinical effects of NT5C2 mutations in relapsed ALL, we analyzed NT5C2 in 455 relapsed B-cell precursor...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Barz, Malwine J., Hof, Jana, Groeneveld-Krentz, Stefanie, Loh, Jui Wan, Szymansky, Annabell, Astrahantseff, Kathy, von Stackelberg, Arend, Khiabanian, Hossein, Ferrando, Adolfo A., Eckert, Cornelia, Kirschner-Schwabe, Renate
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218751/
https://ncbi.nlm.nih.gov/pubmed/31971569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002499
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