Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia

Activating mutations in cytosolic 5′-nucleotidase II (NT5C2) are considered to drive relapse formation in acute lymphoblastic leukemia (ALL) by conferring purine analog resistance. To examine the clinical effects of NT5C2 mutations in relapsed ALL, we analyzed NT5C2 in 455 relapsed B-cell precursor...

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Publicado en:Blood
Autores principales: Barz, Malwine J., Hof, Jana, Groeneveld-Krentz, Stefanie, Loh, Jui Wan, Szymansky, Annabell, Astrahantseff, Kathy, von Stackelberg, Arend, Khiabanian, Hossein, Ferrando, Adolfo A., Eckert, Cornelia, Kirschner-Schwabe, Renate
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2020
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218751/
https://ncbi.nlm.nih.gov/pubmed/31971569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002499
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