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Discovery of endogenous inverse agonists for G protein-coupled receptor 6

The orphan G protein-coupled receptor 6 (GPR6) is highly expressed in the striatum and1 has been linked to multiple striatal pathologies. The identification of endogenous ligands and their mechanisms of action at GPR6 will help to elucidate the physiological and pathological roles of the receptor. I...

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Publicado en:Biochem Biophys Res Commun
Autores principales: Shrader, Sarah H., Song, Zhao-Hui
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218748/
https://ncbi.nlm.nih.gov/pubmed/31818461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.12.004
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