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Discovery and characterization of novel smallmolecule agonists of G protein-coupled receptor 119

AIM: GPR119 is a G protein-coupled receptor (GPCR) that is highly expressed in pancreatic β-cells and intestinal L-cells and facilitates glucose-stimulated insulin secretion (GSIS). GPR119 may represent a novel target for the treatment of metabolic disorders. Here, we sought to identify novel small-...

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Publicado no:Acta Pharmacol Sin
Main Authors: Zhang, Shu-yong, Li, Jing, Xie, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813729/
https://ncbi.nlm.nih.gov/pubmed/24681896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.8
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