Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells

Natural killer (NK) cells expressing chimeric antigen receptors (CARs) are a promising anticancer immunotherapy, leveraging both innate NK cell antitumor activity and target-specific cytotoxicity. Inducible MyD88/CD40 (iMC) is a potent, rimiducid-regulated protein switch that has been deployed previ...

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Bibliographische Detailangaben
Veröffentlicht in:Blood Adv
Hauptverfasser: Wang, Xiaomei, Jasinski, Daniel L., Medina, Jan L., Spencer, David M., Foster, Aaron E., Bayle, J. Henri
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Immunobiology and Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218419/
https://ncbi.nlm.nih.gov/pubmed/32384544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001510
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